|
ADME STUDIES IN HEALTHY VOLUNTEERS |
 | ADME STUDIES IN HEALTHY VOLUNTEERS
I.P.A.S. has implemented a specific clinical and laboratory facility for the absorption, distribution, metabolism and excretion (ADME) studies with radiolabelled drugs administered to healthy volunteers..
CLINICAL UNIT
• Suitably featured hospitalisation and sampling rooms
• Specifically trained physicians, nurses and monitors | | | RADIO-ANALYTICAL LAB
• Radioactivity determination in systemic fluids (blood and plasma) and excreta (urine, faeces and breath) by liquid scintillation counting and oxygen combustion techniques
• Determination of radiolabelled drug in biological fluids by HPLC with radiometric detector
• Metabolic profiles in biological fluids
• Mass balance
EQUIPMENT
• LKB-Wallac beta and gamma-counters
• Sample Oxidizer Model 307, Packard Instruments
• Radiometric detector Flo-one/beta, Packard Instruments. |  |
|
ADME STUDIES IN HEALTY VOLUNTEERS